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GHRH Analog (DAC)
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that extends its half-life significantly. By binding to albumin in the bloodstream, it achieves a half-life of 6-8 days compared to minutes for native GHRH. It is commonly used in research for its ability to increase GH and IGF-1 levels in a pulsatile, physiological manner.
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CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that extends its half-life significantly. By binding to albumin in the bloodstream, it achieves a half-life of 6-8 days compared to minutes for native GHRH. It is commonly used in research for its ability to increase GH and IGF-1 levels in a pulsatile, physiological manner.
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
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Peer-reviewed scientific literature on CJC-1295 from PubMed, NEJM, The Lancet, and other authoritative sources.
Teichman SL, Neale A, Lawrence B, et al.
Journal of Clinical Endocrinology & Metabolism, 91: 799–805 (2006)
CJC-1295 produced dose-dependent increases in mean GH concentrations (2- to 10-fold) and IGF-1 levels (1.5- to 3-fold) that were sustained for 6–8 days after a single injection, demonstrating its extended pharmacodynamic profile.
Walker RF.
Rejuvenation Research, 9: 200–205 (2006)
The combination of a GHRH analog with a GHRP produces synergistic GH release exceeding either compound alone, with the GHRH component amplifying GH pulse amplitude and the GHRP component increasing pulse frequency.