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Long-acting Amylin Analog
Cagrilintide is a long-acting amylin analog that acts as a non-selective amylin receptor agonist. It regulates satiety, delays gastric emptying, and has demonstrated significant efficacy in metabolic research. It shows particularly powerful synergistic effects when combined with GLP-1 receptor agonists like semaglutide.
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Cagrilintide is a long-acting amylin analog that acts as a non-selective amylin receptor agonist. It regulates satiety, delays gastric emptying, and has demonstrated significant efficacy in metabolic research. It shows particularly powerful synergistic effects when combined with GLP-1 receptor agonists like semaglutide.
Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH₂
Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH₂ (Disulfide bridge: Cys2-Cys7)
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Peer-reviewed scientific literature on Cagrilintide from PubMed, NEJM, The Lancet, and other authoritative sources.
Lau DCW, et al.
The Lancet, 398: 2160–2172 (2021)
Cagrilintide treatment resulted in significant dose-dependent weight loss compared to placebo, with the 4.5 mg dose leading to a mean weight reduction of 10.8% at 26 weeks.
Enebo SR, et al.
The Lancet, 397: 1736–1748 (2021)
The combination of cagrilintide and semaglutide 2.4 mg was well tolerated and produced greater weight loss (17.1% at 20 weeks) than semaglutide alone (9.8%), demonstrating a powerful synergistic effect.