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Growth Hormone Secretagogue
Ipamorelin is a selective growth hormone secretagogue and ghrelin mimetic. Unlike other GH secretagogues, it selectively stimulates GH release without significantly affecting cortisol, prolactin, or ACTH levels. This high selectivity makes it an ideal research compound for studying GH-related physiology. It is frequently combined with CJC-1295 for synergistic effects.
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Ipamorelin is a selective growth hormone secretagogue and ghrelin mimetic. Unlike other GH secretagogues, it selectively stimulates GH release without significantly affecting cortisol, prolactin, or ACTH levels. This high selectivity makes it an ideal research compound for studying GH-related physiology. It is frequently combined with CJC-1295 for synergistic effects.
Aib-His-D-2Nal-D-Phe-Lys-NH₂
Aib-His-D-2Nal-D-Phe-Lys-NH₂
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Peer-reviewed scientific literature on Ipamorelin from PubMed, NEJM, The Lancet, and other authoritative sources.
Raun K, Hansen BS, Johansen NL, et al.
European Journal of Endocrinology, 139: 552–561 (1998)
Ipamorelin demonstrated the highest selectivity for GH release among known secretagogues, with minimal effects on cortisol, prolactin, or ACTH—establishing it as the first truly selective GH secretagogue with a superior safety profile.
Svensson J, Lönn L, Jansson JO, et al.
Journal of Clinical Endocrinology & Metabolism, 83: 362–369 (1998)
GH secretagogue treatment significantly increased lean body mass, reduced fat mass, and improved muscle protein synthesis rates compared to placebo, with effects correlating with GH pulse amplitude and IGF-1 elevation.